Mark Burger's blog
Exaspiration: Vit D and Immunity
It really is demonstrative this total lack of media attention to an inexpensive, immensely safe ("It seems clear that restoring physiological serum levels of 25(OH)D will help many more patients that it will hurt. In fact, living in America today while worrying about vitamin D toxicity is like dying of thirst in the desert while worrying about drowning."John Cannell, M.D., Vitamin D Council) and incredibly effective (7% reduction in all cancers) therapy.
If there was a drug developed tomorrow that reduced all cancers by 7% it would be front page news.
"Regardless of vitamin D's effects on innate immunity, activated vitamin D is a pluripotent pleiotropic seco-steroid with as many mechanisms of action as the 1,000 human genes it regulates . Evidence continues to accumulate of vitamin D's involvement in a breathtaking array of human disease and death [40,41]." Virology Journal 2008 5:29
"1,25-dihydroxyvitamin D (active form of vitamin D: calcitriol) acts as an immune system modulator, preventing excessive expression of inflammatory cytokines and increasing the 'oxidative burst' potential of macrophages. Perhaps most importantly, it dramatically stimulates the expression of potent anti-microbial peptides, which exist in neutrophils, monocytes, natural killer cells, and in epithelial cells lining the respiratory tract where they play a major role in protecting the lung from infection." Epidemiology & Infection 2006 Dec:134(6):1129-40
According to research from this newly published study by Cedric F. Garland, Dr.P.H., FACE, "It is projected that raising the minimum year-around serum 25(OH)D level to 40-60 ng/ml (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three quarters of deaths from these diseases, in the US and Canada."
THIS IS WHAT IS WRONG WITH HEALTH CARE AND DRUG DEVELOPMENT IN PARTICULAR! PROFITS BEFORE PATIENTS.