New Class of Potential Drugs Inhibits Inflammation in Brain
News Category: Clinical News
02/15/2012 0 Comments Contact Our News Editors
Scientists at Emory University School of Medicine have identified a new group of compounds that may protect brain cells from inflammation linked to seizures and neurodegenerative diseases.
The compounds block signals from EP2, one of the four receptors for prostaglandin E2, which is a hormone involved in processes such as fever, childbirth, digestion and blood pressure regulation. Chemicals that could selectively block EP2 were not previously available. In animals, the EP2 blockers could markedly reduce the injury to the brain induced after a prolonged seizure, the researchers showed. The results were published online in the Proceedings of the National Academy of Sciences Early Edition.